fumarate

American  

[fyoo-muh-reyt] / ˈfyu məˌreɪt /

noun

Biochemistry.

1. the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.

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fumarate Scientific  

/ fyo̅o̅′mə-rāt′ /

1. A salt or ester of fumaric acid, in which one or both of the hydrogen atoms in the carboxyl groups of the fumaric acid have been replaced with another element or group.

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Etymology

Origin of fumarate

First recorded in 1860–65; fumar(ic acid) + -ate ²

Example Sentences

When the researchers administered fumarate to aging T-cells in mice and human tissue, they found lower levels of mitophagy.

From Science Daily • Oct. 10, 2025

When fumarate levels drop, cells recycle too many of their healthy mitochondria, resulting in a loss of strength.

From Science Daily • Oct. 10, 2025

Water is added to fumarate during step seven, and malate is produced.

From Textbooks • Jun. 9, 2022

Pre-exposure prophylaxis, known as PrEP, is a combination of two drugs — tenofovir disoproxil fumarate and emtricitabine — made by Gilead Sciences and marketed as Truvada.

From Washington Post • Nov. 20, 2018

It is a yellowish oil which melts at -24� C.; it boils at 143-144� C., but cannot be distilled safely as it decomposes violently, giving nitrogen and ethyl fumarate.

From Encyclopaedia Britannica, 11th Edition, Volume 8, Slice 4 "Diameter" to "Dinarchus" by Various