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can't do anything with

Unable to cope with or manage someone or something. For example, I can't do anything with my hair, or My teenage daughter is very difficult—I can't do anything with her. This expression uses do in the sense of “deal with,” a usage dating from the early 1500s.
The American Heritage® Idioms Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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