cardinal symptom

cardinal symptom in Medicine

cardinal symptom n.
The primary or major symptom by which a diagnosis is made.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Historical Examples

Here, indeed, lies properly the cardinal symptom of the whole wide-spread malady.

The French Revolution Thomas Carlyle

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