- a disease characterized by abnormal accumulations of facial and trunk fat, fatigue, hypertension, and osteoporosis, caused by hyperfunction of the adrenal cortex or administration of adrenal cortical hormones.
Origin of Cushing's disease
1935–40; after H. W. Cushing, who first described it
Also called Cushing's syndrome.
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
- a rare condition caused by excess corticosteroid hormones in the body, characterized chiefly by obesity of the trunk and face, high blood pressure, fatigue, and loss of calcium from the bones
C20: named after Harvey Williams Cushing (1869–1939), US neurosurgeon
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
- A syndrome caused by an increased production of ACTH from a tumor of the adrenal cortex or of the anterior lobe of the pituitary gland. It is characterized by obesity and weakening of the muscles.Cushing's basophilism Cushing's disease pituitary basophilism
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
- A syndrome caused by an excess of corticosteroids, especially cortisol, in the blood, characterized by obesity, muscle and skin atrophy, facial fullness (known as moon facies), hypertension, and other physical changes. Glucocorticoid excess is usually caused by a tumor of the adrenal cortex, excessive intake of ACTH or glucocorticoids, or increased production of ACTH from a tumor of the anterior lobe of the pituitary gland. Cushing's syndrome is named after its discoverer, American neurosurgeon Harvey Williams Cushing (1869-1939).
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.