dukkha is the contrary of this: uneasiness, discomfort, difficulty.
in Buddhism, the first of the Four Noble Truths, that life is constantly changing and therefore full of suffering, specif. due to attachment and excessive desire; an understanding that the nature of life is suffering and impermanence; also written duhkha , dukkhata
The other three Noble Truths explain the origins of dukkha and the means for eliminating dukkha.
Sanskrit, Pali translated variously, including'truth, the truth of suffering'