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endogenous depression

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noun Psychiatry.
  1. a severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events.
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Origin of endogenous depression

First recorded in 1960–65
Also called melancholia.
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

endogenous depression in Medicine

endogenous depression

n.
  1. A group of symptoms that resemble depression but are not precipitated by a stressful experience, especially psychomotor agitation or retardation, insomnia and early morning awakening, weight loss, excessive guilt, and lack of reactivity to one's environment.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.