1590s, "bewitch, enchant," from Middle French fasciner (14c.), from Latin fascinatus, past participle of fascinare "bewitch, enchant, fascinate," from fascinus "spell, witchcraft," of uncertain origin. Possibly from Greek baskanos "bewitcher, sorcerer," with form influenced by Latin fari "speak" (see fame (n.)).
The Greek word might be from a Thracian equivalent of Greek phaskein "to say;" cf. also enchant, and German besprechen "to charm," from sprechen "to speak." Earliest used of witches and of serpents, who were said to be able to cast a spell by a look that rendered one unable to move or resist. Sense of "delight, attract" is first recorded 1815. Related: Fascinated; fascinating.