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[gahr-goi-liz-uh m]
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noun Pathology.
  1. a congenital abnormality characterized chiefly by dwarfism, grotesque deformities of the head, trunk, and limbs, mental retardation, and enlargement of the liver and spleen.

Origin of gargoylism

First recorded in 1935–40; gargoyle + -ism
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
gargoylism in Medicine


  1. A condition characterized by coarsened facial surface and distorted features and associated with Hurler's syndrome and Hunter's syndrome.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.