general paralysis of the insane

British  

noun

1.  GPI.  Also called: general paresis.   dementia paralytica.  a disease of the central nervous system: a late manifestation of syphilis, often occurring up to 15 years after the original infection, characterized by mental deterioration, speech defects, and progressive paralysis

---

Example Sentences

Toward the end of the century, as many as one in five people entering asylums had general paralysis of the insane.

From The New Yorker • May 20, 2019

The pair took pus from the sores of syphilitics and injected it into patients suffering from general paralysis of the insane.

From The New Yorker • May 20, 2019

He had to be committed to the Northern State Hospital, where he died of "general paralysis of the insane."

From Time Magazine Archive

Again, what shall we do in cases of paresis, or general paralysis of the insane, an affliction which probably invariably has syphilis as its antecedent?

From Being Well-Born An Introduction to Eugenics by Guyer, Michael F.

A combination of tabes with lateral sclerosis, or with general paralysis of the insane, is sometimes seen, but needs no special consideration.

From Fat and Blood An Essay on the Treatment of Certain Forms of Neurasthenia and Hysteria by Mitchell, John K.