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[hahy-druh-klawr-ahyd, -id, -klohr-]
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  1. a salt, especially of an alkaloid, formed by the direct union of hydrochloric acid with an organic base that makes the organic constituent more soluble.

Origin of hydrochloride

First recorded in 1820–30; hydro-2 + chloride
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for hydrochloride

Historical Examples

  • The nitrate and hydrochloride are at present much used in pharmacy.

    Poisons: Their Effects and Detection

    Alexander Wynter Blyth

  • The hydrochloride is soluble in alcohol and in water, melting-point about 205°.

  • The hydrochloride crystallises in white plates, and has a melting-point of 192°.

  • Hydrochloride of nicotine is more easily volatilised than the pure base.

  • It gives a precipitate with potassium iodide if a solution of the hydrochloride be used.

British Dictionary definitions for hydrochloride


  1. a quaternary salt formed by the addition of hydrochloric acid to an organic base, such as aniline hydrochloride, [C 6 H 5 NH 3 ] + Cl -
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

hydrochloride in Medicine


([object Object])
  1. A compound resulting from the reaction of hydrochloric acid with an organic base.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

hydrochloride in Science


  1. A salt containing the group HCl. Many important drugs are hydrochlorides.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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