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Synonyms

idiopathic

American  
[id-ee-uh-path-ik] / ˌɪd i əˈpæθ ɪk /

adjective

Pathology.
  1. of unknown cause, as a disease.


idiopathic Scientific  
/ ĭd′ē-ə-păth′ĭk /
  1. Relating to or being a disease having no known cause.


Other Word Forms

Etymology

Origin of idiopathic

First recorded in 1660–70; idio- + -pathic

Explanation

When your doctor isn't sure why you're sick, she might describe your illness as idiopathic, doctor-speak for "of unknown causes." The medical term idiopathic comes from Greek roots: idios, or "one's own," and pathos, "suffering" or "disease." The literal meaning is something like "a disease of its own," or an illness that isn't connected to any particular cause. This is often the diagnosis doctors end up with after ruling out a lot of known conditions or diseases, and it's an official-sounding way for a medical professional to say "I don't know why you're sick."

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Vocabulary lists containing idiopathic

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

In a study published in Nature Biotechnology, researchers evaluated Insilico’s investigational drug—known as rentosertib—for idiopathic pulmonary fibrosis, an age-related lung disease.

From The Wall Street Journal ● Sep. 7, 2026

It’s acquiring Centessa Pharmaceuticals, which is working on orexin receptor 2 agonists for conditions like narcolepsy and idiopathic hypersomnia — forms of daytime sleepiness.

From MarketWatch ● Mar. 31, 2026

The mother of two has idiopathic laryngotracheal stenosis, a rare condition that affects one in 500,000 women and causes abnormal narrowing of the voice box and windpipe.

From BBC ● Dec. 30, 2025

Its first-generation candidate, ORX750, is aimed at treating three types of severe narcolepsy—type I, type II, and idiopathic hypersomnia.

From Barron's ● Sep. 26, 2025

I once Googled “excessive blushing” and found out there’s a terrifying name for my condition: idiopathic craniofacial erythema.

From "Insignificant Events in the Life of a Cactus" by Dusti Bowling

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