Old English stice "a prick, puncture," from Proto-Germanic *stikiz, from the root of stick (v.). The sense of "sudden, stabbing pain in the side" was in late Old English. Senses in sewing and shoemaking first recorded late 13c.; meaning "bit of clothing one is (or isn't) wearing" is from c.1500. Meaning "a stroke of work" (of any kind) is attested from 1580s. Surgical sense first recorded 1520s. Sense of "amusing person or thing" is 1968, from notion of laughing so much one gets stitches of pain (cf. verbal expression to have (someone) in stitches, 1935).
early 13c., "to stab, pierce," also "to fasten or adorn with stitches;" see stitch (n.). Related: Stitched; stitching.
A sudden sharp pain, especially in the side.
A single suture.
Laughing very hard (1935+)