The minimum lethal dose by mouth is the same as by subcutaneous, and is less than by intraperitoneal, injection.
The rupture of the tube may be intraperitoneal or extraperitoneal.
The best illustration is the testicular reaction of young male guinea-pigs to intraperitoneal injections of glanders bacilli.
When introduced by the intraperitoneal route, caffein is, on the contrary, distinctly less toxic.
It should be added that Holst and Froelich failed to cure scurvy in guinea-pigs by intraperitoneal inoculations of orange juice.
In intraperitoneal rupture immediate operation affords the only chance of saving life.
Three methods of injection of antigen were used in various combinations: intravenous, subcutaneous, and intraperitoneal.