early 15c., from Middle French lesion, from Latin laesionem (nominative laesio) "injury," from past participle stem of laedere "to strike, hurt, damage," of unknown origin. Originally with reference to any sort of hurt, whether physical or not.
lesion le·sion (lē'zhən)
A wound or an injury.
A localized pathological change in a bodily organ or tissue.
An infected or diseased patch of skin.