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[meth-oh-trek-seyt] /ˌmɛθ oʊˈtrɛk seɪt/
noun, Pharmacology.
a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.
Origin of methotrexate
1950-55; metho(xy)- + trexate, of unclear derivation Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2017.
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British Dictionary definitions for methotrexate


/ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-/
an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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methotrexate in Science
A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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