misfold
Americanverb (used without object)
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
See Examples For:
When proteins misfold, they can form abnormal clusters called Lewy bodies, which build up within brain cells stopping them from functioning properly.
From Science Daily ● Apr. 17, 2024
CJD is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
From Science Magazine ● Mar. 21, 2024
The research suggests that SARS-CoV-2 can cause normal proteins to abnormally misfold.
From Salon ● Apr. 24, 2023
A mutation in the gene that provides instructions for producing the transthyretin protein causes it to misfold and deposit in the body’s tissue and organs, disrupting normal function.
From Washington Post ● Feb. 5, 2022
We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold.
From Scientific American ● Jun. 22, 2021
"Our goal was to examine how these partner proteins coordinate proinsulin folding and remove any misfolded mistakes, as these steps are essential for the health of insulin-producing cells."
From Science Daily ● Jul. 28, 2026
Together, the findings indicate that mGluR4 and NPDC1 work as partners to transport misfolded α-synuclein into neurons, at least in mice.
From Science Daily ● Jul. 12, 2026
It looked at 17 studies, involving 20,342 volunteers, of drugs that remove amyloid - a misfolded protein present in disease - from the brain.
From BBC ● May 22, 2026
When tau becomes misfolded, it starts clumping together into long, fibrous aggregates known as fibrils.
From Science Daily ● Nov. 15, 2025
"Ketone bodies interact with damaged and misfolded proteins directly, making them insoluble so they can be pulled from the cell and recycled."
From Science Daily ● Dec. 2, 2024
The response prevents proteins in the recipient tissues from misfolding.
From Science Magazine ● May 22, 2024
But there is a common denominator, namely protein misfolding and the occurrence of protein deposits in the brain.
From Science Daily ● Dec. 4, 2023
"The assumption used to be that every neurodegenerative disease was characterized by the misfolding of a specific protein," explains Jörg Tatzelt.
From Science Daily ● Dec. 4, 2023
In the context of prolonging our health, this means that nature will have discovered many ways of combating the inherently destructive processes of life, such as free-radical damage and protein misfolding.
From Salon ● Aug. 20, 2022
Diminished expression of heat-shock protein genes in humans could raise the risk of illnesses, such as Alzheimer’s disease, in which the misfolding of proteins is implicated, the researchers report in their paper.
From Scientific American ● Mar. 22, 2022
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
