misfold
Americanverb (used without object)
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
See Examples For:
But proteins will sometimes misfold even in a healthy cell.
From Science Daily ● Apr. 30, 2024
CJD is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
From Science Magazine ● Mar. 21, 2024
Specifically, amyloids occur when proteins misfold into twisted clumps and form long fibers, hindering cellular function.
From Salon ● Apr. 24, 2023
A mutation in the gene that provides instructions for producing the transthyretin protein causes it to misfold and deposit in the body’s tissue and organs, disrupting normal function.
From Washington Post ● Feb. 5, 2022
We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold.
From Scientific American ● Jun. 22, 2021
Instead, in people who already had these plaques, physical activity reduced the accumulation of misfolded tau proteins in specific brain areas.
From Science Daily ● Oct. 19, 2026
The E3 ligase enzyme cleans up the cell, tagging proteins that are damaged or misfolded for destruction.
From The Wall Street Journal ● Oct. 15, 2026
The investigators also identified additional partner proteins involved in folding and transporting proinsulin, as well as detecting and managing misfolded versions.
From Science Daily ● Jul. 28, 2026
A new study published in Nature Communications points to two membrane proteins, mGluR4 and NPDC1, as critical transporters that help carry the misfolded protein into healthy brain cells.
From Science Daily ● Jul. 12, 2026
It looked at 17 studies, involving 20,342 volunteers, of drugs that remove amyloid - a misfolded protein present in disease - from the brain.
From BBC ● May 22, 2026
Protein misfolding has been implicated as the underlying cause of a range of human diseases, notably Alzheimer's, Huntington's, and Parkinson's.
From Science Daily ● May 30, 2024
“The mechanisms are similar,” says David Harris, a neuroscientist at the Boston University Medical Center who is working to identify small molecules to block prion misfolding.
From Science Magazine ● Mar. 21, 2024
Studies on genes associated with pathologies have revealed two basic mechanisms by which misfolded proteins can lead to neurodegeneration: Firstly, misfolding can cause the protein to acquire toxic activity.
From Science Daily ● Dec. 4, 2023
In the context of prolonging our health, this means that nature will have discovered many ways of combating the inherently destructive processes of life, such as free-radical damage and protein misfolding.
From Salon ● Aug. 20, 2022
Diminished expression of heat-shock protein genes in humans could raise the risk of illnesses, such as Alzheimer’s disease, in which the misfolding of proteins is implicated, the researchers report in their paper.
From Scientific American ● Mar. 22, 2022
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