early 15c., "endurance, fortitude," from Old French tolerance (14c.), from Latin tolerantia "endurance," from tolerans, present participle of tolerare "to bear, endure, tolerate" (see toleration). Of authorities, in the sense of "permissive," first recorded 1530s; of individuals, with the sense of "free from bigotry or severity," 1765. Meaning "allowable amount of variation" dates from 1868; and physiological sense of "ability to take large doses" first recorded 1875.
tolerance tol·er·ance (tŏl'ər-əns)
Decreased responsiveness to a stimulus, especially over a period of continued exposure.
The capacity to absorb a drug continuously or in large doses without adverse effect; diminution in the response to a drug after prolonged use.
Physiological resistance to a poison.
Acceptance of a tissue graft or transplant without immunological rejection.
Unresponsiveness to an antigen that normally produces an immunological reaction.
The ability of an organism to resist or survive infection by a parasitic or pathogenic organism.