- c1545–1644, Algonquian leader, brother of Powhatan: led Jamestown massacre 1622.
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
Examples from the Web for opechancanough
This, with a genial manner, he would present to Opechancanough.Pioneers of the Old South
If you like not the look of things, find out where Opechancanough is, and I'll send him an embassy.
"Let Opechancanough go with me to-day to Jamestown," I said.
Opechancanough has many thoughts which he shares with no man.
Opechancanough is our head, and Opechancanough kindleth a fire indeed!