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osteodermatopoikilosis os·te·o·der·ma·to·poi·ki·lo·sis (ŏs'tē-ō-dûr'mə-tō-poi'kə-lō'sĭs)n. Osteopoikilosis with skin lesions on the back of the thighs and buttocks. Also called Buschke-Ollendorf syndrome.