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panhypopituitarism pan·hy·po·pi·tu·i·ta·rism (pān'hī-pō-pĭ-tōō'ĭ-tə-rĭz'əm, -tyōō'-)n. A state in which secretion of the anterior pituitary hormones is inadequate or absent as a result of destruction of the anterior pituitary gland.