The respiration is at first accelerated by a dose of physostigmine, but is afterwards slowed and ultimately arrested.
After subcutaneous or local application, a dilatation neutralised by physostigmine in moderate doses.
The clinical uses of physostigmine are based upon the facts of its pharmacology, as above detailed.
physostigmine contracts the iris to a point; the action is quite local, and is confined to the eye to which it is applied.
Each of these contains one-thousandth part of a grain of physostigmine sulphate, a quantity which is perfectly efficient.
There is a marked antagonism in nearly all important particulars between the actions of physostigmine and of atropine.
physostigmine phy·so·stig·mine (fī'sō-stĭg'mēn') or phy·so·stig·min (-mĭn)
A crystalline alkaloid used in medicine as a miotic and cholinergic agent and to enhance memory in patients with Alzheimer's disease. Also called eserine.