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proinsulin

American

[proh-in-suh-lin, -ins-yuh-] / proʊˈɪn sə lɪn, -ˈɪns jə- /

noun

Biochemistry.

the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule.

Etymology

Origin of proinsulin

First recorded in 1915–20; pro- ¹ + insulin

Example Sentences

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See Examples For:

proinsulin

Their beta cells made smaller amounts of both proinsulin and insulin.

From Science Daily ● Jul. 28, 2026

Reintroducing the protein improved the cells' ability to fold and transport proinsulin while reducing the accumulation of improperly folded copies.

From Science Daily ● Jul. 28, 2026

When researchers genetically removed p58IPK from two different cell lines, misfolded proinsulin accumulated at higher levels.

From Science Daily ● Jul. 28, 2026

No current therapies are designed to improve proinsulin folding in order to preserve the health and function of beta cells.

From Science Daily ● Jul. 28, 2026

Wheeler's colleagues in Brazil inserted a segment of human DNA coding for proinsulin -- the protein precursor of the active form of insulin -- into cell nuclei of 10 cow embryos.

From Science Daily ● Mar. 13, 2024

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Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023