Another detail may be significant, but more delicate--Dean has long suffered from almost disabling arthritis.
Perhaps the most significant structural flaw in the current system, however, is that the fox is guarding the henhouse.
By receiving a stake in Vornado, the Kennedy heirs deferred a significant portion of the sale's capital-gains tax.
However, there are significant differences to Hirst and Choe that help collapse the comparison.
In the end, it turns out that in significant ways, our humanity turns on our ability dispatch with a handful of Doritos.
I exposed to him the conclusion we in Brussels had arrived at, and pointed out the significant series of failures.
The involvement of language, in particular of writing and reading, is significant.
The secret lies chiefly in passing quickly from one significant point to another.
Probably just as significant is the role mediation plays in the process.
The manner in which the losses thus caused were repaired is significant and instructive.
1570s, "having a meaning," from Latin significantem (nominative significans, present participle of significare "make known, indicate" (see signify). Earlier in the same sense was significative (c.1400). Often "having a special or secret meaning," hence "important" (1761). Related: Significantly. Significant figure is from 1680s. Significant other (n.) attested by 1961, in psychology, "the most influential other person in the patient's world."