somatostatin so·mat·o·stat·in (sō-māt'ə-stāt'n, sō'mə-tə-)
A tetradecapeptide capable of inhibiting the release of somatotropin by the pituitary gland. Also called somatotropin release-inhibiting factor.
A polypeptide produced by the hypothalamus and the pancreas. Somatostatin produced by the hypothalamus acts as a neurohormone that inhibits the secretion of other hormones, especially growth hormone and thyrotropin. Somatostatin secreted by the pancreas acts as a hormone that inhibits the secretion of the other pancreatic hormones, insulin and glucagon, and reduces the activity of the digestive system.