topoisomerase
Americannoun
-
topoisomerases
plural
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Camptothecin is one of several topoisomerase I–inhibiting cancer drugs that have received approval from the Food and Drug Administration.
From Science Magazine ● Apr. 28, 2016
The team’s findings suggest that topoisomerase I also helps orchestrate the immune system’s response to pathogen attacks.
From Science Magazine ● Apr. 28, 2016
Camptothecin kills cancer cells by blocking the enzyme topoisomerase I, which removes kinks from DNA so that it can be duplicated or read to produce proteins.
From Science Magazine ● Apr. 28, 2016
Marazzi says that he and his colleagues are working with a pharmaceutical company to organize a clinical trial to test whether blocking topoisomerase I is beneficial during sepsis.
From Science Magazine ● Apr. 28, 2016
Other noteworthy genes were APEX1, a multifunctional DNA repair enzyme, RFC1, replication factor C, and TOP2A, a DNA topoisomerase that controls the topologic states of DNA during transcription.
From Nature ● Nov. 15, 2011
These are resolved with the action of topoisomerases.
From Textbooks ● Jun. 9, 2022
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