late 13c., "superior, ruler, master," from Old French soverain "sovereign, lord, ruler," noun use of adjective meaning "highest, supreme, chief" (see sovereign (adj.)). Meaning "gold coin worth 22s 6d" first recorded late 15c.; value changed 1817 to 1 pound.
early 14c., "great, superior, supreme," from Old French soverain "highest, supreme, chief," from Vulgar Latin *superanus "chief, principal" (source also of Spanish soberano, Italian soprano), from Latin super "over" (see super-). Spelling influenced by folk-etymology association with reign. Milton spelled it sovran, as though from Italian sovrano. Of remedies or medicines, "potent in a high degree," from late 14c.