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virulent

American  
[vir-yuh-luhnt, vir-uh-] / ˈvɪr yə lənt, ˈvɪr ə- /

adjective

  1. actively poisonous; intensely noxious.

    a virulent insect bite.

    Synonyms:
    venomous
    Antonyms:
    harmless
  2. Medicine/Medical. highly infective; malignant or deadly.

  3. Bacteriology. causing clinical symptoms.

  4. violently or spitefully hostile.

  5. intensely bitter, spiteful, or malicious.

    a virulent attack.

    Synonyms:
    acerbic, vicious

virulent British  
/ ˈvɪrʊlənt /

adjective

    1. (of a microorganism) extremely infective

    2. (of a disease) having a rapid course and violent effect

  1. extremely poisonous, injurious, etc

  2. extremely bitter, hostile, etc

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Derived Forms

Etymology

Origin of virulent

1350–1400; Middle English verulent < Latin vīrulentus, equivalent to vīr ( us ) poison ( see virus) + -ulentus -ulent

Explanation

A virulent disease is one that's infectious, spreading, and making lots of people sick, while a virulent rant is just a verbal attack, causing sickness of the emotional kind. Either way, something virulent puts a strain on the people who get it. Two meanings come out of the roots for virulent: "poisonous" and "spiteful." The virus-carrying meaning of virulent often gets combined with strain, such as in a "virulent strain of the flu." Those who aren’t carrying disease but are still considered virulent most likely lash out at others with a biting tone. Unleashing acid-tongued words on someone would be considered a virulent attack.

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Vocabulary lists containing virulent

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Valencia is hoping to become Colombia's first woman president, and as a senator has gained a reputation as one of the most virulent critics of guerrilla groups and the left.

From Barron's • May 25, 2026

The traditional method of creating flu vaccines involves growing the virus in eggs - but this can be a problem when there are virulent avian flu strains which can kill the eggs used during manufacturing.

From BBC • Apr. 21, 2026

But time travel is an imperfect science, and the technician overseeing the process is delirious from a virulent new strain of flu, so Kivrin is accidentally dropped into 1348, the year of the Black Death.

From The Wall Street Journal • Feb. 17, 2026

"The bumpier, irregular surface of the virulent strains exposes parts of the virus that are normally hidden, allowing certain antibodies to attach more easily," Dr. Bibby said.

From Science Daily • Nov. 27, 2025

Myth number three: MDR was less virulent and contagious than regular TB.

From "Mountains Beyond Mountains" by Tracy Kidder and Michael French

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