histocompatibility

American  

[his-toh-kuhm-pat-uh-bil-i-tee] / ˌhɪs toʊ kəmˌpæt əˈbɪl ɪ ti /

noun

Immunology.

1. the condition of having antigenic similarities such that cells or tissues transplanted from one (the donor) to another (the recipient) are not rejected.

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histocompatibility British  

/ ˌhɪstəʊkəmˌpætɪˈbɪlɪtɪ /

noun

1. the degree of similarity between the histocompatibility antigens of two individuals. Histocompatibility determines whether an organ transplant will be tolerated

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histocompatibility Scientific  

/ hĭs′tō-kəm-păt′ə-bĭl′ĭ-tē /

1. A state or condition in which the absence of immunological interference permits the grafting of tissue or the transfusion of blood without rejection.

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Other Word Forms

Derived Forms

• histocompatible
  adjective

Etymology

Origin of histocompatibility

First recorded in 1945–50; histo- + compatibility ( def. )

Example Sentences

Researchers believe that a particular group of genes, the major histocompatibility complex, play a large role in scent production.

From Scientific American • Sep. 26, 2023

Doherty won the Nobel Prize for medicine in 1996 with his Swiss colleague Rolf Zinkernagel for “their discoveries concerning the specificity of the cell-mediated immune defence and the biological role of the major histocompatibility complex”.

From The Guardian • Apr. 27, 2020

While that statistic might not enhance the mood, the special sharing is thought to be helpful in sampling the partner’s histocompatibility genes involved in immune response.

From Washington Post • Oct. 16, 2019

Wearsch, P. A. & Cresswell, P. Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin–ERp57 heterodimer.

From Nature • Nov. 5, 2017

They do not recognize self-antigens, however, but only processed antigen presented on their surfaces in a binding groove of a major histocompatibility complex molecule.

From Textbooks • Jun. 19, 2013