DNA repair

Cultural  

1. The way in which a cell corrects potentially damaging or mutagenic errors in its DNA. (See mutagen.) DNA bases may be directly replaced by enzymes, or part of a strand may be replaced by enzymes using its opposite, paired strand as a template.

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Example Sentences

They tested olaparib, a drug commonly used against BRCA-mutant cancers that targets cellular DNA repair pathways.

From Science Daily • Jun. 20, 2026

When cancer cells were exposed to UNI418, levels of critical DNA repair proteins, including RAD51 and CHK1, dropped significantly.

From Science Daily • Jun. 10, 2026

The researchers tested whether disabling DNA repair in this way could improve the effectiveness of existing therapies.

From Science Daily • Jun. 10, 2026

Co-corresponding author Director Kyungjae Myung remarked, "This study demonstrates that controlling the stability of DNA repair proteins can directly impact cancer cell survival. It also highlights a new therapeutic direction for overcoming drug resistance."

From Science Daily • Jun. 10, 2026

These findings suggest that cancer cells remain heavily dependent on DNA repair pathways, even after they have developed resistance to therapy.

From Science Daily • Jun. 10, 2026