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predispose

American  
[pree-di-spohz] / ˌpri dɪˈspoʊz /

verb (used with object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give an inclination or tendency to beforehand; make susceptible.

    Genetic factors may predispose human beings to certain metabolic diseases.

    Synonyms:
    prepare, prearrange
  2. to render subject, susceptible, or liable.

    The evidence predisposes him to public censure.

  3. to dispose beforehand.

    Synonyms:
    incline, bias
  4. Archaic. to dispose of beforehand, as in a will, legacy, or the like.


verb (used without object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give or furnish a tendency or inclination.

    an underground job that predisposes to lung infection.

predispose British  
/ ˌpriːdɪˈspəʊz /

verb

  1. to incline or make (someone) susceptible to something beforehand

  2. law to dispose of (property, etc) beforehand; bequeath

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

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Etymology

Origin of predispose

First recorded in 1640–50; pre- + dispose


Explanation

Predispose means to have a tendency toward something. Some people believe that just being born in Canada will predispose you to love ice hockey. Many situations or events can predispose you to have a particular reaction, opinion, or feeling. Being bitten by a dog as a child could predispose you to having a fear of dogs. Having ancestors with great athletic ability might predispose you to enjoy running. If you want to predispose your father to liking your new boyfriend, be sure to tell him about volunteering at the food bank and leave out the bits about his arrest and dropping out of school.

Keep Reading on Vocabulary.com

Vocabulary lists containing predispose

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Recognizing this, some oncologists have begun administering drugs with restraint rather than abandon, aiming to keep the cancer in check rather than creating conditions that predispose to the rapid growth of resistant cells.

From The Wall Street Journal ● Apr. 20, 2026

"The whole team undertakes a standardized warm-up that addresses a number of physical concerns that predispose our female athletes to ACLs," she said.

From BBC ● Jun. 30, 2025

Their goal was to pinpoint what biological conditions might predispose some people to the problem.

From Los Angeles Times ● Mar. 12, 2025

Nothing in her environment would predispose her to cancer, except for being in close proximity to the fires.

From Slate ● Jan. 16, 2025

Attitudes such as these certainly predispose one to innumeracy.

From "Innumeracy: Mathematical Illiteracy and Its Consequences" by John Allen Paulos

Nor does it hurt that the extraordinary popularity of the Harry Potter movies predisposes much of the audience to sympathy and affection.

From The Wall Street Journal ● Mar. 13, 2026

Studies show that adding sugar to any food for babies or small children predisposes them to having a sweet tooth.

From Salon ● Apr. 25, 2024

"On the other hand, if telomeres are too long, it predisposes you to certain types of cancer."

From Science Daily ● Apr. 11, 2024

People with two copies of the APOE4 gene, which predisposes to Alzheimer’s, may be at higher risk of ARIA.

From Science Magazine ● Jan. 6, 2023

There is something which predisposes an invalid to all narratives of illness; they are the topics he dwells on with most pleasure, and discourses about with most eagerness.

From Arthur O'Leary His Wanderings And Ponderings In Many Lands by Charles James Lever

Certain breeds are predisposed to heart or orthopedic issues, for example, that can be expensive to treat.

From MarketWatch ● Sep. 15, 2026

"This situation could lead to many of the students ending up in a vulnerable situation and predisposed to being further exploited financially or otherwise," Juho Sillanpää, who is leading the investigation, told the BBC.

From BBC ● Jun. 12, 2026

"Exosomes are used to communicate with and activate surrounding cells, and we have now identified a defect in both the production and the quality of exosomes in cells that we know are predisposed to Alzheimer's."

From Science Daily ● Nov. 25, 2025

Wojcicki said inquiries poured into 23andMe in 2015 after actor Angelina Jolie disclosed that she’d undergone a precautionary double mastectomy upon learning she carried a gene that predisposed her to breast cancer.

From Los Angeles Times ● Mar. 26, 2025

These same internal stirrings also predisposed him to regard all perfectly symmetrical narratives or stories preaching an obvious moral message and populated by larger-than-life heroes as utter fabrications.

From "Founding Brothers: The Revolutionary Generation" by Joseph J. Ellis

There may also be "predisposing factors", such as trauma, issues from early childhood, or negative self-belief, that can make it harder to curb your use, she says.

From BBC ● Aug. 8, 2026

“Inadequate nutrition, particularly vitamin A deficiency, can impair the lining of the digestive tract, predisposing birds to inflammation and secondary illness.”

From Los Angeles Times ● Apr. 20, 2026

Fifteen potentially harmful and predisposing variants in the same RNF207 and PRKAA2 genes, which had been identified in dogs, were discovered in humans.

From Science Daily ● Sep. 22, 2023

“The difference is likely due to a combination of stress and inflammation, arising from predisposing factors and the way this virus biologically interacts with the cardiovascular system.”

From Seattle Times ● Oct. 26, 2022

Was there anything about the Chinese environment predisposing toward Confucian philosophy and cultural conservatism, which may also have profoundly affected history?

From "Guns, Germs, and Steel: The Fates of Human Societies" by Jared M. Diamond

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