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acantholysis

(ăk′ăn-thŏlĭ-sĭs, ăk′ən-)
n. pl. ac•an•thol•y•ses (-sēz′)
  1. Separation of individual prickle cells from their neighbors, as in keratosis follicularis.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.