active site

American  

noun

Biochemistry.

1. the part of an enzyme that interacts with the substrate during catalysis.

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active site Scientific  

1. The part of an enzyme where the catalytic activity on the substrate takes place.

2. See more at enzyme

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active site Cultural  

1. The part of an enzyme or antibody where a chemical reaction occurs.

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Etymology

Origin of active site

First recorded in 1960–65

Example Sentences

ATP is the central energy carrier of the cell which supports numerous molecular processes, while, histidine is the most common amino acid found in the active site of enzymes, and maintains their acid-base chemistry.

From Science Daily • Apr. 18, 2024

In M. thermolithotrophicus, the 2-oxoglutarate binds in a pocket far away from the active site where the reaction takes place.

From Science Daily • Jan. 22, 2024

Forest Service stipulates that the observatory must remain an active site for research, astronomy or education — or be dismantled down to its last historic bolt.

From Los Angeles Times • Oct. 3, 2023

The active site is where the “action” happens.

From Textbooks • Apr. 25, 2013

The chemical properties that emerge from the particular arrangement of amino acid R groups within an active site create the perfect environment for an enzyme’s specific substrates to react.

From Textbooks • Apr. 25, 2013