allosteric

American  

[al-uh-ster-ik, -steer-] / ˌæl əˈstɛr ɪk, -ˈstɪər- /

adjective

Biochemistry.

1. pertaining to regulation of the rate of an enzymatic process.

---

allosteric British  

/ ˌæləʊˈstɪərɪk /

adjective

1. biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule

---

Other Word Forms

• allosterically adverb

Etymology

Origin of allosteric

First recorded in 1960–65; allo- + steric

Example Sentences

"While enzyme and allosteric regulation which controls metabolism was suppressed in typical mice during feeding, we were surprised to find that the reverse occurred in obese mice and that this activity increased."

From Science Daily • Feb. 26, 2024

Researchers at the Centre for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS.

From Science Daily • Dec. 18, 2023

Drugs that target allosteric sites are generally safer and more effective compared to drugs targeting active sites.

From Science Daily • Dec. 18, 2023

Additionally, ATP is an allosteric regulator of some of the enzymes involved in the catabolic breakdown of sugar, the process that creates ATP.

From Textbooks • Apr. 25, 2013

When an allosteric inhibitor binds to a region on an enzyme, all active sites on the protein subunits are changed slightly such that they bind their substrates with less efficiency.

From Textbooks • Apr. 25, 2013