antisense

American  

[an-tee-sens, an-tahy‑] / ˌæn tiˈsɛns, ˌæn taɪ‑ /

adjective

1. of or relating to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.

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antisense Scientific  

/ ăn′tē-sĕns′,ăn′tī- /

1. Relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

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Etymology

Origin of antisense

First recorded in 1985–90

Example Sentences

"Although morpholinos themselves are not an option because of their toxicity, similar strategies, like antisense oligonucleotide therapies already used in other conditions, could potentially be developed for Rett syndrome."

From Science Daily • Mar. 6, 2026

Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

From Science Daily • Nov. 25, 2024

Ultimately, antisense might be used in commercial operations to prevent maturation without genetically modifying the fish.

From Science Magazine • Feb. 9, 2023

In 1992, a geneticist at the University of Hawaii in Honolulu used antisense technology to insert a gene that blocks an enzyme in the caffeine-making pathway.

From Slate • Jan. 11, 2023

These tensions have increased since the recent death of a child who received a customized antisense drug.

From New York Times • Dec. 19, 2022