antisense

American  

[an-tee-sens, an-tahy‑] / ˌæn tiˈsɛns, ˌæn taɪ‑ /

adjective

1. of or relating to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.

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antisense Scientific  

/ ăn′tē-sĕns′,ăn′tī- /

1. Relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

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Etymology

Origin of antisense

First recorded in 1985–90

Example Sentences

The study showed that when the researchers injected a compound called BCC10 linked to specialized genetic tools known as antisense oligonucleotides into mice, it successfully reduced the activity of harmful genes in the brain.

From Science Daily • Nov. 25, 2024

The treatment uses therapeutic molecules called antisense oligonucleotides, or ASOs, that can alter the expression of genes through interactions with RNA, which creates proteins.

From Science Daily • Mar. 4, 2024

Ultimately, antisense might be used in commercial operations to prevent maturation without genetically modifying the fish.

From Science Magazine • Feb. 9, 2023

In 1992, a geneticist at the University of Hawaii in Honolulu used antisense technology to insert a gene that blocks an enzyme in the caffeine-making pathway.

From Slate • Jan. 11, 2023

He and other scientists are studying whether other antisense drugs might cause the same problem.

From New York Times • Dec. 19, 2022