antisense

American  

[an-tee-sens, an-tahy‑] / ˌæn tiˈsɛns, ˌæn taɪ‑ /

adjective

1. of or relating to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.

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antisense Scientific  

/ ăn′tē-sĕns′,ăn′tī- /

1. Relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

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Etymology

Origin of antisense

First recorded in 1985–90

Example Sentences

Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

From Science Daily • Nov. 25, 2024

In the new study, the researchers describe how this can be achieved using the so-called "antisense" method.

From Science Daily • Feb. 29, 2024

Ultimately, antisense might be used in commercial operations to prevent maturation without genetically modifying the fish.

From Science Magazine • Feb. 9, 2023

In 1992, a geneticist at the University of Hawaii in Honolulu used antisense technology to insert a gene that blocks an enzyme in the caffeine-making pathway.

From Slate • Jan. 11, 2023

These tensions have increased since the recent death of a child who received a customized antisense drug.

From New York Times • Dec. 19, 2022