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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[may-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[may-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

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Example Sentences

See Examples For:

mayo Mayo

Burger King, owned by Restaurant Brands International, earlier this year improved the bun, box, mayo and other elements of its Whopper.

From The Wall Street Journal ● Aug. 6, 2026

It has a gloss to it, a kind of quiet sheen that standard mayo simply does not.

From Salon ● Apr. 14, 2026

A single distribution network that served them with small packets of shampoo as well as jars of mayo made sense.

From The Wall Street Journal ● Mar. 20, 2026

The miso mayo is great as a marinade for steak or chicken thighs.

From The Wall Street Journal ● Feb. 11, 2026

Dad held up a knife covered with mayo.

From "Lawn Boy" by Gary Paulsen

Researchers at Mayo Clinic have identified five biologically distinct forms of the condition, each associated with different risks of serious health complications, including heart disease, liver failure, cancer, and the need for a liver transplant.

From Science Daily ● Oct. 19, 2026

N.G., and J.L.K. have a financial interest related to this research, including patents and pending patents covering senolytic drugs and their uses that are held by Mayo Clinic.

From Science Daily ● Oct. 14, 2026

“It’s not hitting the tax return in the short term,” said Mayo.

From The Wall Street Journal ● Oct. 8, 2026

According to Mayo Clinic, the condition causes temporary weakness or paralysis of facial muscles, and Brolin felt there was “nothing else to blame” for the symptoms.

From MarketWatch ● Oct. 7, 2026

In the three months between his surgery and his death, Gey went to the Mayo Clinic in Minnesota for a week of treatments with an experimental Japanese drug that made him violently ill.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot

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