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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[mey-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[mey-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

Example Sentences

See Examples For:

mayo Mayo

It has a gloss to it, a kind of quiet sheen that standard mayo simply does not.

From Salon ● Apr. 14, 2026

Chia seeds are a nutrient-dense replacement for eggs, meaning you can make plant-based cookies and even plant-based mayo.

From Salon ● Mar. 31, 2026

The deal will put condiment brands such as Hellmann’s mayo, Old Bay seasoning, Knorr, and Lawry’s under the same umbrella.

From The Wall Street Journal ● Mar. 31, 2026

A single distribution network that served them with small packets of shampoo as well as jars of mayo made sense.

From The Wall Street Journal ● Mar. 20, 2026

We’ll probably be eating tuna, peas, and mayo for dinner.

From "A Place at the Table" by Saadia Faruqi and Laura Shovan

Bronkhorst’s stomach-cancer treatment was developed by Shanghai-based CARsgen Therapeutics, which won Chinese approval for the solid tumor CAR-T therapy following a clinical-trial program that included U.S. patients at MD Anderson and Mayo Clinic in Minnesota.

From The Wall Street Journal ● Sep. 7, 2026

Meningitis is an infection and swelling of the fluid and membranes around the brain and spinal cord, according to the Mayo Clinic.

From Los Angeles Times ● Aug. 27, 2026

Wells Fargo bank analyst Mike Mayo called the vocabulary Moynihan uses on calls an “intellectual flex” and said it was better to keep it simple.

From The Wall Street Journal ● Aug. 17, 2026

Back to that 2016 Cinco de Mayo photo of himself enjoying a taco salad sold at his Trump Hotel in Manhattan.

From Los Angeles Times ● Aug. 13, 2026

For Christmas, Carol gives me some Friendship’s Garden bath salts and Grace gives me a coloring book of Virginia Mayo.

From "Cat's Eye" by Margaret Atwood