either of two genes (BRCA1 or BRCA2) that, if inherited in a mutated form, may predispose some carriers to develop breast or ovarian cancer.

Origin of BRCA

1900–95; initialism from br(east) and ca(ncer) Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Examples from the Web for brca1

  • The case centers around Myriad, which has patents on BRCA1 and BRCA2, genes that are linked to a very high risk of breast cancer.

    It’s in the Genes|Megan McArdle|June 13, 2013|DAILY BEAST

Medicine definitions for brca1




A tumor suppressor gene that, when inherited in a mutated state, is associated with the development of various cancers, especially breast and ovarian cancer.

The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

Science definitions for brca1



One of two genes (designated BRCA1 and BRCA2) that help repair damage to DNA, but when inherited in a defective state increase the risk of breast and ovarian cancer.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.