1. either of two genes (BRCA1 or BRCA2) that, if inherited in a mutated form, may predispose some carriers to develop breast or ovarian cancer.

Origin of BRCA

1900–95; initialism from br(east) and ca(ncer) Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for brca1

Contemporary Examples of brca1

  • The case centers around Myriad, which has patents on BRCA1 and BRCA2, genes that are linked to a very high risk of breast cancer.

    The Daily Beast logo
    It’s in the Genes

    Megan McArdle

    June 13, 2013

brca1 in Medicine


  1. A tumor suppressor gene that, when inherited in a mutated state, is associated with the development of various cancers, especially breast and ovarian cancer.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

brca1 in Science


  1. One of two genes (designated BRCA1 and BRCA2) that help repair damage to DNA, but when inherited in a defective state increase the risk of breast and ovarian cancer.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.