carboxylation

[kahr-bok-suh-ley-shuhn]

noun

1. the process of carboxylating.

Word History and Origins

Origin of carboxylation¹

carboxyl + -ation

Example Sentences

Aside from their practical applications, these findings indicate that reductive carboxylation is not required for the proliferation of CD8+ T cells, as it appears to be for rapidly growing cancer cells.

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Ho says his team now plans to examine how best to sabotage reductive carboxylation to prepare better cells for CAR-T and other adoptive T cell therapies, comparing pharmacologic inhibition with gene editing strategies to that end.

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In the absence of oxygen, cancer cells resort to a very specific survival mechanism: they metabolise the amino acid glutamine as an alternative source of energy through a chemical reaction known as ''reductive carboxylation''.

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To investigate the role of reductive carboxylation, the scientists inhibited this mechanism in CAR-T cells in mouse models of leukemia and multiple myeloma, two blood cancers.

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Reductive carboxylation acts directly on the generation of metabolites, small chemical elements that modify histones, to influence DNA packaging and to prevent accessibility to longevity genes.

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