a cattle trail leading N from San Antonio, Tex., to Abilene, Kan.: used for about twenty years after the Civil War.
Origin of Chisholm Trail
named after Jesse Chisholm (1806–68), American scout
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019
1866, from Jesse Chisholm (c.1806-1868), halfbreed Cherokee trader and government agent who first plied it. The surname is from a barony in England, probably from Old English cisel "gravel."
Online Etymology Dictionary, © 2010 Douglas Harper