A sterol found widely in animal and plant tissues. It is a main component of blood plasma and cell membranes, and it is an important precursor of many steroid hormones (such as the estrogens, testosterone, and cortisol), vitamin D2, and bile acids. In vertebrates, cholesterol is manufactured by the liver or absorbed from food in the intestine. Higher than normal amounts of cholesterol in the blood are associated with higher risk for developing coronary artery disease and atherosclerosis. Chemical formula: C27H46O. See also high-density lipoprotein low-density lipoprotein.

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