clofibrate

[kloh-fahy-breyt, -fib-reyt]

noun

Pharmacology.

1. a substance, C 12 H 15 ClO 3 , used principally to reduce elevated plasma triglyceride and cholesterol levels.

Word History and Origins

Origin of clofibrate¹

1960–65; clofibr(ic acid) (perhaps c(h)lo(ro)- ² + fibr- + -ic ) + -ate ²

Example Sentences

So the authors put clofibrate into the water of normal male mice, and mice that had the human TAS1R3 gene.

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When these mice were given the drug clofibrate, which inhibits the human receptor, the males became sterile due to malformed and fewer sperm.

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And if you got rid of the clofibrate?

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The drug clofibrate that belongs to a class of chemicals called fibrates, which are frequently prescribed to treat lipid disorders, such as high blood cholesterol or high levels of triglycerides.

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The mice quickly became fertile again once clofibrate was removed from their diet.

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