creatine

American  

[kree-uh-teen, -tin] / ˈkri əˌtin, -tɪn /

noun

Biochemistry.

1. an amino acid, C 4 H 9 N 3 O 2 , that is a constituent of the muscles of vertebrates and is phosphorylated to store energy used for muscular contraction.

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creatine British  

/ ˈkriːətɪn, ˈkriːəˌtiːn, -tɪn /

noun

1. an important metabolite involved in many biochemical reactions and present in many types of living cells

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creatine Scientific  

/ krē′ə-tēn′,-tĭn /

1. A nitrogenous organic acid that is found in the muscle tissue of vertebrates, mainly combined with phosphorus, and that supplies energy for muscle contraction. Chemical formula: C ₄ H ₉ N ₃ O ₂ .

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Etymology

Origin of creatine

First recorded in 1830–40; creat- (from Greek kreat-, stem of kréas “flesh”) + -ine ² ( def. )

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Compare meaning

How does creatine compare to similar and commonly confused words? Explore the most common comparisons:

• creatine vs. creatinine

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Example Sentences

See Examples For:

creatine

“Vegetarians can benefit from creatine supplementation because they’re not consuming the foods that have higher amounts of creatine, like red meat and salmon, which have 1-2 grams per pound.”

From Los Angeles Times ● Oct. 19, 2026

For those over 40, creatine can not only help counteract age-related muscle loss, but “it can be helpful for bone health,” Zaslow says.

From Los Angeles Times ● Oct. 19, 2026

For adults, the recommended daily dose of creatine is three to five grams.

From Los Angeles Times ● Oct. 19, 2026

More research is needed to better understand the connection between creatine and cognition; but the supplement may be beneficial for brain health, particularly in older adults and for issues related to sleep deprivation.

From Los Angeles Times ● Oct. 19, 2026

So notorious is this that it used to be held that the specific poison of glanders was generated in connection with the excess of creatine, creatinine, and lactic acid resulting from muscular action.

From A System of Practical Medicine by American Authors, Vol. I Volume 1: Pathology and General Diseases by Various

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