creatine

American  

[kree-uh-teen, -tin] / ˈkri əˌtin, -tɪn /

noun

Biochemistry.

1. an amino acid, C 4 H 9 N 3 O 2 , that is a constituent of the muscles of vertebrates and is phosphorylated to store energy used for muscular contraction.

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creatine British  

/ -tɪn, ˈkriːətɪn, ˈkriːəˌtiːn /

noun

1. an important metabolite involved in many biochemical reactions and present in many types of living cells

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creatine Scientific  

/ krē′ə-tēn′,-tĭn /

1. A nitrogenous organic acid that is found in the muscle tissue of vertebrates, mainly combined with phosphorus, and that supplies energy for muscle contraction. Chemical formula: C ₄ H ₉ N ₃ O ₂ .

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Etymology

Origin of creatine

First recorded in 1830–40; creat- (from Greek kreat-, stem of kréas “flesh”) + -ine ² ( def. )

Compare meaning

How does creatine compare to similar and commonly confused words? Explore the most common comparisons:

• creatine vs. creatinine

Example Sentences

In addition to physical performance, creatine may also support certain aspects of brain function.

From Science Daily • May 4, 2026

"With sufficient justification, appropriate dosage form, and dosing regimen, creatine may eventually be recognized as an over-the-counter therapeutic agent rather than merely a dietary supplement."

From Science Daily • May 4, 2026

However, the body can only store a limited amount of creatine, and individual levels vary.

From Science Daily • May 4, 2026

Research shows that it increases creatine and phosphocreatine levels in muscle, which improves the body's ability to regenerate ATP during short bursts of high intensity activity.

From Science Daily • May 4, 2026

Creatinine is produced from creatine with great facility; it exists in urine.

From The Chemistry of Food and Nutrition by Duncan, A. W.