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demyelination

American  
[dee-mahy-uh-luh-ney-shuhn] / ˌdi maɪ ə ləˈneɪ ʃən /

noun

  1. loss of myelin from the nerve sheaths, as in multiple sclerosis.


Etymology

Origin of demyelination

First recorded in 1930–35; de- + myelination

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

MS is defined by ongoing inflammation and demyelination within the central nervous system.

From Science Daily • Jan. 6, 2026

After three weeks, mice that received cisplatin but not gamma therapy showed many of the expected effects of chemotherapy: brain volume shrinkage, DNA damage, demyelination, and inflammation.

From Science Daily • Mar. 6, 2024

The resulting demyelination impairs the functioning of nerve cells and can result in optic neuritis, vision loss, nausea and fatigue.

From Washington Post • Jan. 14, 2022

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

From Nature • Nov. 14, 2017

Unrelated work7 has shown that germ-free mice are protected from an experimentally induced condition similar to multiple sclerosis, which is characterized by demyelination of nerve fibres.

From Nature • Oct. 13, 2015

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