differentiation
Americannoun
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the act or process of differentiating, or the state of being differentiated.
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Mathematics. the operation of finding the differential or derivative of a function.
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Biology. the process by which cells or tissues change from relatively generalized to specialized kinds, during development.
noun
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the act, process, or result of differentiating
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maths an operation used in calculus in which the derivative of a function or variable is determined; the inverse of integration See integration
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any process in which a mixture of materials separates out partially or completely into its constituent parts, as in the cooling and solidification of a magma into two or more different rock types or in the gradual separation of an originally homogeneous earth into crust, mantle, and core
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In calculus, the process of computing the derivative of a function.
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Compare integration
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The process by which cells or parts of an organism change during development to serve a specific function. The cells of an animal in its early embryonic phase, for example, are identical at first but develop by differentiation into specific tissues, such as bone, heart muscle, and skin. The factors determining the differentiation of any particular cell are not well understood, but in deuterostomes (vertebrates and other complex animals) they include the location of the cell relative to other cells.
Etymology
Origin of differentiation
First recorded in 1800–10; differentiat(e) + -ion
Explanation
Differentiation is how someone or something is set apart from others. If you make a differentiation between one brand of toothpaste and another, you point out how they're distinct. You can see the word different in differentiation. The -tion ending tips you off that differentiation is the noun form of different: differentiation refers to the differences themselves. Suppose two very similar movies come out at the same time. The studios will work to achieve differentiation in the films' trailers, with one highlighting the chemistry between the romantic leads and the other showing moments of slap-stick comedy.
Vocabulary lists containing differentiation
Cell Biology - Middle School
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Cell Biology - High School
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STAAR Biology: Cell Structure and Function
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Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
However, the firm sees a path toward differentiation in the market between Viridian and Amgen.
From Barron's • Apr. 6, 2026
El Pollo Loco may be just the right combination of price and differentiation from fast-food burgers at a time when consumers are looking to save.
From Los Angeles Times • Mar. 13, 2026
Markets allow firms to compete on differentiation, even when the differentiation is of questionable value to consumers.
From The Wall Street Journal • Feb. 13, 2026
“This differentiation could drive higher enterprise win rates, translating into cloud growth and profitability upside,” Post wrote of Alphabet’s proprietary infrastructure.
From MarketWatch • Feb. 5, 2026
There was frequently some element of truth in these essential lines of differentiation.
From "The Boys in the Boat: Nine Americans and Their Epic Quest for Gold at the 1936 Berlin Olympics" by Daniel James Brown
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Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.