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diphenoxylate

American  
[dahy-fen-ok-suh-leyt] / ˌdaɪ fɛnˈɒk səˌleɪt /

noun

Pharmacology.

  1. a substance, C 30 H 32 N 2 O 2 , used in the form of its hydrochloride in the treatment of diarrhea.

Etymology

Origin of diphenoxylate

diphen(yl) + ox- + -yl + -ate 2

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The research team examined patients using a range of treatments, including Food and Drug Administration-approved IBS drugs, antidepressants, antispasmodics and opioid-based antidiarrheal medications such as loperamide and diphenoxylate, which are commonly recommended for symptom relief.

From Science Daily • Apr. 16, 2026

But the same amount of medication was available under its generic name, diphenoxylate, for only $3.29.

From Time Magazine Archive

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.