Down syndrome

American  

Or Down's syndrome

noun

Pathology.

1. a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental impairment, weak muscle tone, shorter stature, and a flattened facial profile.

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Sensitive Note

Down syndrome (or Down's syndrome ) has replaced earlier terms, such as mongolism to refer to the disease and Mongoloid or Mongol to refer to the affected person, all of which are now considered offensive.

Etymology

Origin of Down syndrome

First recorded in 1960–65; after John L. H. Down (1828–96), British physician

Example Sentences

See Examples For:

Down syndrome

He said there were countless videos featuring the AI-generated figures with Down syndrome and said the same accounts had been trying to sell identical products using elderly synthetic characters.

From Barron's ● Jun. 18, 2026

We heard from a mother, Opal Foster, whose 18-year-old son has Down syndrome and lives at home as he strives to become a chef.

From Salon ● Apr. 29, 2026

In 2024, the most popular Fashionistas dolls globally included the blind Barbie and the Barbie with Down syndrome.

From Los Angeles Times ● Jan. 12, 2026

The Eriksons also had a fourth child, Neil, who had Down syndrome and was sent to an institution immediately after birth.

From The Wall Street Journal ● Dec. 18, 2025

She leans down, handing her baby with Down syndrome chunky plastic blocks from the toy basket.

From "Rules" by Cynthia Lord