Down syndrome

American  

Or Down's syndrome

noun

Pathology.

1. a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental impairment, weak muscle tone, shorter stature, and a flattened facial profile.

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Sensitive Note

Down syndrome (or Down's syndrome ) has replaced earlier terms, such as mongolism to refer to the disease and Mongoloid or Mongol to refer to the affected person, all of which are now considered offensive.

Etymology

Origin of Down syndrome

First recorded in 1960–65; after John L. H. Down (1828–96), British physician

Example Sentences

See Examples For:

Down syndrome

The videos "crowd-out" posts from actual entrepreneurs with Down syndrome, potentially siphoning away business, Rowe said.

From Barron's ● Jun. 18, 2026

YouTuber Jesse Ridgway and his wife, Ashley, shared that they terminated their pregnancy following a Down syndrome diagnosis.

From Los Angeles Times ● Jun. 5, 2026

We heard from a mother, Opal Foster, whose 18-year-old son has Down syndrome and lives at home as he strives to become a chef.

From Salon ● Apr. 29, 2026

The Eriksons also had a fourth child, Neil, who had Down syndrome and was sent to an institution immediately after birth.

From The Wall Street Journal ● Dec. 18, 2025

There was already a special education class in the school, but Charlie became the first kid with Down syndrome to attend Montgomery Middle.

From "Marcus Vega Doesn't Speak Spanish" by Pablo Cartaya