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endogenous depression

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noun Psychiatry.

a severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events.

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Also called melancholia.

Origin of endogenous depression

First recorded in 1960–65
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2021

Medical definitions for endogenous depression

endogenous depression

n.

A group of symptoms that resemble depression but are not precipitated by a stressful experience, especially psychomotor agitation or retardation, insomnia and early morning awakening, weight loss, excessive guilt, and lack of reactivity to one's environment.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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