a severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events.
Origin of endogenous depression
First recorded in 1960–65
Also called melancholia.
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019
Medicine definitions for endogenous depression
A group of symptoms that resemble depression but are not precipitated by a stressful experience, especially psychomotor agitation or retardation, insomnia and early morning awakening, weight loss, excessive guilt, and lack of reactivity to one's environment.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.